Ambrohexal drops instructions for use for children. Ambroxol oral and inhalation solution

Ambrohexal: instructions for use and reviews

Ambrohexal is an expectorant and mucolytic drug used in the treatment of respiratory diseases.

Release form and composition

The drug is released in the form:

  • Round white tablets containing 30 mg of ambroxol hydrochloride and excipients: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium carboxymethyl starch, magnesium stearate, colloidal silicon dioxide. In blisters of 10 pieces;
  • Long-acting hard gelatin capsules containing 75 mg of ambroxol hydrochloride and excipients: microcrystalline cellulose, Eudragit RL30D and RS30D, triethyl citrate, magnesium stearate, titanium dioxide, iron oxide dye red. In blisters of 10 pieces;
  • A colorless solution for inhalation and oral administration containing 1 ml (1 ml = 20 drops) of 7.5 mg of ambroxol hydrochloride and excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium disulfite, citric acid, sodium hydroxide, water. In dropper bottles of 50 ml;
  • Yellowish syrup containing 1 ml of 3 or 6 mg of ambroxol hydrochloride and excipients: benzoic acid, sodium disulfite, citric acid monohydrate, sodium hydroxide, povidone, sorbitol 70% solution, 85% glycerol, sodium cyclamate, raspberry flavor, purified water. In dark bottles of 100 ml with a measuring spoon.

Pharmacological properties

Pharmacodynamics

Ambroxol - the active component of Ambrohexal - is characterized by expectorant, secretolytic and secretomotor action. It stimulates the work of the serous cells of the glands located in the bronchial mucosa, increases the production of mucous secretions and enhances the release of a surfactant (surfactant) in the bronchi and alveoli. Ambroxol also normalizes the disturbed balance of the mucous and serous components of sputum and reduces the viscosity of sputum by activating enzymes responsible for hydrolysis and promoting the release of lysosomes from Clara cells. This compound intensifies the motor activity of the ciliated epithelium, activates mucociliary transport and facilitates the process of removing sputum from the respiratory tract.

Usually, the therapeutic effect of oral ambroxol is observed after 30 minutes and lasts 6-12 hours, depending on the size of the dose taken.

Pharmacokinetics

When taken orally, Ambroxol is absorbed quickly and almost completely. The maximum concentration of the substance in this case is reached 1-3 hours after ingestion.

Ambroxol is metabolized in the liver, forming metabolites excreted in the urine (glucuronides, dibromanthranilic acid). It is approximately 85% bound to plasma proteins. The plasma half-life is 7-12 hours. The total half-life of ambroxol and its metabolites is approximately 22 hours. 90% of the compound is excreted through the kidneys as metabolites. Less than 10% of ambroxol is excreted unchanged in the urine.

Since ambroxol binds to proteins to a large extent and has a large volume of distribution, and is also characterized by slow reverse penetration from tissues into the blood, forced diuresis or dialysis does not significantly affect its excretion. In patients with severe hepatic dysfunction, ambroxol clearance is reduced by 20-40%. In severe renal failure, the half-life of ambroxol metabolites increases. Also, the substance easily penetrates the placental barrier and into breast milk.

Indications for use

Ambrohexal is prescribed for the treatment of:

  • Acute and chronic diseases of the respiratory tract, characterized by the formation of a viscous secret;
  • Bronchial asthma with difficulty in sputum discharge;
  • Chronic obstructive pulmonary disease;
  • pneumonia;
  • Acute and chronic bronchitis;
  • Bronchiectasis.

Syrup and solution for oral and inhalation Ambrohexal is also used for the treatment and prevention of respiratory distress syndrome.

Contraindications

  • First trimester of pregnancy;
  • Hypersensitivity to the active substance (ambroxol) and auxiliary components of the drug.

According to the instructions, Ambrohexal in the form of tablets is allowed from 6 years old, capsules - from 12 years old.

With caution, the medication is prescribed for lactating women, as well as against the background of:

  • Peptic ulcer of the stomach and duodenum (due to the risk of a possible exacerbation of the disease);
  • Renal and liver failure.

Instructions for use Ambrohexal: method and dosage

Ambrohexal syrup for children over 12 years of age and adults is prescribed 3 times a day, 2 scoops (30 mg). Maximum - 120 mg per day. After the condition improves, it is recommended to reduce the frequency of administration to 2 times a day.

For children, syrup is used according to the following scheme:

  • Children 6-12 years old - one scoop 2-3 times a day;
  • Children 2-5 years old - 0.5 measuring spoons 3 times a day;
  • Children under two years old - 0.5 scoops 2 times a day.

For children over 12 years old and adults, the first few days of treatment are prescribed 1 tablet of Ambrohexal 3 times a day, after which the frequency of use should be reduced to 2 times a day. A single dosage for children 6-12 years old is 1/2 tablet.

Capsules are taken after meals in the morning or evening. The daily dosage for adults and children from 12 years old is 1 capsule.

Solution for oral and inhalation Ambrohexal is usually prescribed 3 times a day, 4 ml (30 mg). After improvement of the condition, the frequency rate is reduced to 2 times a day. For children 5-12 years old, the maximum daily dose of the drug in this dosage form is 45 mg, divided into several doses, for children 2-5 years old - 15 mg. The solution is taken after meals, adding it to tea, fruit juice, milk or water.

Inhalations with Ambrohexal solution are shown up to 2 times a day. Single dosage for all age groups - 2-3 ml.

The duration of treatment is determined by the doctor individually, depending on the indications and the severity of the course of the disease. A doctor's supervision is necessary when taking the drug for longer than 4-5 days.

Side effects

The drug may cause:

  • Urticaria;
  • Contact allergic dermatitis;
  • skin rash;
  • Angioedema;
  • Anaphylactic shock;
  • dry mouth;
  • diarrhea
  • Headache;
  • Weakness;
  • nausea;
  • vomiting;
  • Rhinorrhea;
  • Constipation;
  • gastralgia.

When using Ambroxol in high doses, nausea, diarrhea, vomiting, and dyspepsia may also occur. For treatment, induce vomiting, wash the stomach, eat fat-containing foods.

Overdose

Overdose symptoms include increased salivation (when taking syrup 6 mg / ml), dyspepsia, nausea, vomiting, gastralgia, diarrhea. It is recommended to immediately stop taking the drug, induce artificial vomiting and flush the stomach during the first 1-2 hours after the drug enters the body. The use of fatty foods and symptomatic therapy will also help improve the patient's condition.

special instructions

Caution requires the use of Ambrohexal against the background of a weakened cough reflex or impaired mucociliary transport, since there is a risk of sputum accumulation.

Against the background of severe impairment of liver or kidney function, the use of lower concentrations of Ambrohexal or an increase in the interval between doses of the drug is indicated.

Against the background of bronchial asthma, Ambrohexal can contribute to an increase in cough.

During drug therapy, breathing exercises are not recommended. Against the background of a severe course of the disease, it is necessary to aspirate liquefied sputum.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Ambrohexal does not adversely affect the ability to drive a car and work with mechanisms of increased complexity.

Use during pregnancy and lactation

Ambrohexal is prohibited for use in the first trimester of pregnancy. Its appointment in the II and III trimesters is allowed if the possible benefit of treatment for the mother significantly outweighs the potential risks to the fetus.

Ambroxol easily crosses the placental barrier. The results of animal experiments confirmed that the drug does not have a significant effect on embryofetal and postnatal development, as well as childbirth. The active component of the drug is excreted in small amounts in breast milk, so during treatment it is necessary to consider the advisability of stopping breastfeeding.

Ambrohexal - is an effective drug with expectorant and mucolytic action. It contains the main active ingredient - ambroxol hydrochloride. Under its influence, sputum liquefaction occurs, as well as an increase in the ciliary function of the bronchial epithelium, which ensures its excretion. As a conclusion, the main use of this medicinal product is in the treatment of chronic and acute inflammatory diseases of the upper respiratory tract, which are accompanied by the formation of sputum.

What is Ambrohexal prescribed for?

This drug is used to reduce the intensity of coughing, improve expectoration of sputum in adults and children. It is prescribed by doctors for chronic diseases of the lungs and bronchi, accompanied by a weakening of the promotion and separation of mucus, in particular, with:

  • tracheitis;
  • pharyngitis;
  • obstructive bronchitis;
  • rhinitis;
  • acute bronchitis;
  • sinusitis;
  • bronchiectasis;
  • laryngitis.

It is interesting! Doctors prescribe this medicine if there is a possibility of miscarriage in the last trimester of pregnancy, as well as to treat and prevent distress syndrome in premature babies, to stimulate intrauterine maturation of the lungs.

Release form and composition

This medication is available in two dosage forms: in the form of tablets and syrup. The main active ingredient of this drug is ambroxol hydrochloride, the auxiliary components in the syrup are glycerol, apricot flavor, benzoic acid, propylene glycol and levomenthol, and in tablets - lactose monohydrate, corn starch, colloidal silicon dioxide and sodium carboxymethyl starch.

Interaction with other drugs

This medication can be combined with other medications, including diuretics, cardiac glycosides, bronchospasmolytics, and others. However, the simultaneous administration of Ambrohexal and antibiotics leads to an increase in their concentration. Therefore, if you are using any medication and you have been prescribed Ambrohexal, be sure to inform your doctor about it.

Treatment rules

The dosage of this drug depends on the age of the patient, his illness, the nuances of his body, as well as on the form of release of the drug.

  • Syrup. For adults and children over 12 years of age, the recommended daily dosage is 90 mg. With maintenance therapy, doctors advise slightly reducing the dose to 60 mg per day. Children aged 6 to 12 years should take 30 or 45 ml of medication per day, and babies from 2 to 5 years should take 22.5 mg per day. At the same time, doctors advise dividing the daily dose into 2 to 3 doses.
  • Tablets. They should be drunk after eating, drinking plenty of fluids. Children over 12 years of age and adults are recommended to drink 1 tablet 3 times a day during the first 2 to 3 days of therapy. In the future, they need to switch to maintenance treatment and drink 1 tablet 2 times a day. For children aged 6 to 12, the recommended dosage is 1.5 tablets per day, and for toddlers 2 to 6 years, half a tablet per day.

It is worth refusing to treat this medication with hypersensitivity to the components of the drug, with liver and kidney failure, pregnancy and lactation, in children under 6 years of age.

Active substance

Ambroxol*(Ambroxolum)

ATH:

Pharmacological group

Nosological classification (ICD-10)

Compound

Description of the dosage form

Tablets: white, round, flat, with bevelled edges, with a notch on one side.

Capsules: hard gelatin capsules, white body and cap, the contents of the capsules are white and pale pink pellets.

Solution for oral and inhalation: clear colorless solution.

pharmachologic effect

pharmachologic effect- mucolytic, expectorant .

Pharmacodynamics

The drug has an expectorant, mucolytic effect. The decrease in sputum viscosity occurs as a result of the depolymerization of mucopolysaccharides, which are found in sputum. The depolymerization of mucopolysaccharides is associated primarily with the breaking of disulfide bonds in their molecules. Ambroxol increases the motor activity of the ciliated epithelium, increases mucociliary transport, normalizes the ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and increasing the release of lysosomes from Clark cells, it reduces the viscosity of sputum. Facilitates the removal of mucus from the respiratory tract.

Ambroxol stimulates prenatal lung development by increasing the synthesis and secretion of surfactant in the alveoli. Surfactant synthesis is reduced as a result of chronic diseases of the respiratory system, in addition, the properties of the surfactant change due to the formation of bonds between surface-active phospholipids and inflammatory proteins.

Pharmacokinetics

After oral administration, absorption of the drug from the gastrointestinal tract is high. The effect of the drug manifests itself within 30 minutes and lasts 6-12 hours. T max - about 2 hours. Plasma protein binding - 80-90%.

The drug is metabolized in the liver to inactive metabolites (dibromanthranilic acid and glucuronic conjugates). T 1/2 - 7-12 hours.

Penetrates through histohematic barriers, excreted in breast milk. Excreted by the kidneys: 90% - in the form of metabolites, 10% - unchanged.

Indications of the drug

Acute and chronic diseases of the respiratory tract with the release of viscous sputum:

acute and chronic bronchitis;

chronic obstructive pulmonary disease (solution, tablets);

pneumonia;

bronchial asthma with difficulty in sputum discharge;

bronchiectasis;

treatment and prevention of respiratory distress syndrome (solution).

Contraindications

hypersensitivity to any component of the drug;

pregnancy (I trimester);

children's age up to 6 years (tablets), up to 12 years (long-acting capsules).

Carefully: peptic ulcer of the stomach and duodenum (exacerbation of peptic ulcer may occur), renal and liver failure.

Use during pregnancy and lactation

The drug is not recommended for use during the first trimester of pregnancy. If it is necessary to use ambroxol in the II-III trimesters of pregnancy, the potential benefit to the mother with a possible risk to the fetus should be assessed.

During breastfeeding, use the drug with caution, as it is excreted in breast milk.

Side effects

From the digestive system: nausea, vomiting, gastralgia, diarrhea, constipation, dry mouth.

Allergic reactions: skin rash, urticaria, angioedema, paroxysmal bronchospasm, fever with chills, very rarely (< 0,01%) — анафилактический шок.

Others: rare (<1 %): слабость, головная боль, ринорея, усиление слюноотделения, сухость в дыхательных путях, нарушение мочеиспускания (дизурия).

Additionally for oral and inhalation solution

Due to the presence of metabisulfite (preservative) in the composition of sodium, hypersensitivity reactions may develop (especially in patients with bronchial asthma), which manifest themselves in the form of vomiting, diarrhea, acute asthmatic attacks, impaired consciousness or shock. These reactions can be very individual and can also lead to life-threatening consequences.

Interaction

When used with antitussive drugs, sputum discharge may be difficult as a result of suppression of the cough reflex. With simultaneous use with amoxicillin, cefuroxime, erythromycin, doxycycline, ambroxol increases their concentration in bronchial secretions.

Dosage and administration

inside, after meals with plenty of fluids.

Tablets

Adults and children over 12 years of age: 1 tab. (30 mg ambroxol) 3 times a day for the first 2-3 days, then the dose of the drug should be reduced to 1 table. 2 times a day.

Children aged 6 to 12: 1/2 tab. (15 mg ambroxol) 2-3 times a day. It is not recommended to use without a doctor's prescription for more than 4-5 days.

During treatment, it is necessary to consume a lot of fluids (juices, tea, water), because. it enhances the mucolytic effect of the drug.

Long-acting capsules

1 caps. (75 mg ambroxol) per day in the morning or evening after meals, without chewing and drinking plenty of fluids (water, tea or juice).

Solution for oral and inhalation

Adults and children over the age of 12: the first 2-3 days - 3 times 4 ml (30 mg of ambroxol) per day, then - 2 times 4 ml.

Children aged 5-12: 2-3 times a day, 2 ml (15 mg ambroxol).

Children aged 2 to 5 years: 3 times a day, 1 ml (7.5 mg of ambroxol).

Children under 2 years old: 2 times a day, 1 ml (7.5 mg of ambroxol).

Children under the age of 2 years AmbroGEKSAL ® is prescribed only under the supervision of a physician.

AmbroGEXAL ® should be taken diluted after meals with tea, fruit juices, milk or water.

During treatment, it is necessary to drink plenty of fluids (juices, tea, water) to enhance the mucolytic effect of the drug.

Application for inhalation

Adults and children over 5 years of age: it is recommended to inhale 1-2 times a day for 2-3 ml (40-60 drops, which corresponds to 15-22.5 mg of ambroxol).

For inhalation, it is necessary to use a suitable device in compliance with the rules of use.

The duration of therapy depends on the severity of the disease and is determined by the attending physician. AmbroGEXAL ® should not be taken for longer than 4-5 days without a doctor's recommendation.

Overdose

Symptoms: nausea, vomiting, gastralgia. There are reports of short-term restlessness and diarrhea. With a severe overdose, a drop in blood pressure is possible.

Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug, taking fat-containing foods.

special instructions

Ambroxol should be used with caution in patients with a weakened cough reflex or impaired mucociliary transport due to the possibility of sputum accumulation. Patients taking Ambroxol should not be advised to perform breathing exercises; in seriously ill patients, aspiration of diluted sputum should be performed.

In patients with bronchial asthma, ambroxol may increase coughing.

Ambroxol should not be taken immediately before bedtime.

Ambroxol should not be taken concomitantly with antitussive drugs that can inhibit the cough reflex, such as codeine, because. this can make it difficult to remove thinned sputum from the bronchial tree.

Cough is a very common occurrence, especially in the autumn-spring period, so Ambrohexal is often used for inhalation.

But it can have a different origin and character, so we will understand further, for which cough it is advisable to use the medication, how to do inhalations, and what result can be achieved with their help.

Ambrohexal is a line of drugs from the German company LICHTENHELDT, GmbH Pharmazeutische Fabrik for dry and wet cough, accompanied by sputum that is difficult to separate. It is represented by tablets, prolonged-release capsules, syrup, as well as a solution intended for oral and inhalation use.

The composition and medicinal properties of the drug

Ambrohexal solution for oral administration and inhalation is a clear, colorless liquid with pronounced mucolytic and expectorant properties.

As an active ingredient, it contains ambroxol hydrochloride 75 mg for every 10 ml of solution, preservatives, stabilizers and water are used as excipients.

The therapeutic effect of the drug is due to the ability of ambroxol to thin viscous sputum due to the destruction of intermolecular bonds of a special kind.

As well as the activation of the cilia of the bronchial mucosa, which are responsible for the promotion of sputum outward.


The solution is available in dark glass bottles of 50 and 100 ml, equipped with plastic droppers. It also comes with a measuring stick that allows you to accurately measure the required amount of liquid.

Inhalations with Ambrohexal: indications for use

Due to the mucolytic and antitussive action, Ambrohexal is widely used for:

  • acute bronchitis, including obstructive, tracheitis;
  • bronchial asthma;
  • acute pneumonia;
  • and sinusitis of any type;
  • pulmonary tuberculosis;
  • cystic fibrosis, pneumoconiosis, etc.

Thus, the drug can be used in almost any pathology and condition accompanied by excretion, with the exception of diseases of an allergic nature.

The medicine can be taken orally and inhaled with Ambrohexal through a nebulizer. In the second case, bioavailability and the rate of onset of positive changes are much higher, since the active substance penetrates directly into the focus of inflammation and into the mucus, where it immediately begins to work.

Contraindications and possible side effects

Ambrohexal for inhalation cannot be used in the presence of individual intolerance ambroxol or other components of the drug. Also, the annotation does not recommend using it during breastfeeding and pregnancy, especially in the early stages, with the exception of a number of situations.

Questions often arise as to whether they are allowed at subfebrile values, that is, at body temperatures up to 37.5 ° C, at higher rates, manipulation can provoke a deterioration in the condition.
Source: website The drug rarely causes the development of adverse events, however, sometimes there are:

  • allergic reactions in the form of rashes on the skin, itching, extremely rarely - angioedema;
  • nausea and vomiting;
  • heartburn;
  • stomach ache;
  • dry mouth.

Ambrohexal for inhalation: how to dilute with saline

To provide a therapeutic effect, 2-3 ml of the drug is required. How many drops of Ambrohexal do adults need for inhalation?

It is believed that 1 ml of the drug corresponds to 20 drops. Based on this proportion, it is easy to calculate that for one procedure an adult will need 40-60 drops of the product.

Inhalations are performed 1-2 times a day for 5 days. If necessary, but only on the recommendation of a doctor, the course of treatment can be extended.

Inhalation with Ambrohexal can be performed through any type of nebulizer, but you should not use a steam inhaler, as the drug components in it are destroyed. Immediately before the session, the measured amount of the drug is diluted with sterile saline.

Which saline solution to use is an unprincipled question. For this purpose, you can choose ampoules of any volume (2, 5, 10 ml) or purchase a bottle (100, 200, 400 ml).

If in the first case, the required amount of liquid is taken from the ampoule with a syringe, and the remainder is discarded, then in the second, it is enough to pierce the rubber cap of the bottle with a needle and select only the required volume of saline, and store the rest in the refrigerator.

More attention should be paid to how to dilute the drug. It is usually recommended to take an equal amount of both solutions, this will be enough to achieve a therapeutic effect, regardless of the residual volume characteristic of the existing inhaler model.

It is not worth performing the procedure without saline solution, since this will not speed up the onset of recovery, but will only reduce the effectiveness of treatment (if the dose recommended by the annotation is used, since about 1–3 ml will remain in the nebulizer chamber) or lead to an overdose and the development of adverse reactions (if using large amounts of solution).

To properly inhale, you need to breathe evenly and calmly, avoid sharp, deep breaths. Otherwise, a reflex cough may occur.

Another important issue is which nozzle to use on the nebulizer. For adults, a mouthpiece is usually chosen, for children and the elderly who are unable to fully control inhalation and exhalation, a face mask.

How long the manipulation will last depends on the volume of the finished solution and the intensity of the breaths. On average, it takes no more than 10 minutes.

Ambrohexal inhalation for children: dosage and proportions

When conducting inhalation with Ambrohexal and saline for children, how many drops of the agent to inject into the nebulizer chamber depends on the age of the patient. A child from 5 to 12 years old needs 2-3 ml (40-60 drops) of solution for each procedure. It is recommended to carry out 1-2 sessions of inhalation therapy per day.

Manipulation can be carried out through a mask or mouthpiece, however, preference should be given to the second option, since in this case the effectiveness of treatment is higher. The mask is used only when the child is unable to inhale steam through the mouthpiece or it causes him to cough or have other undesirable effects.

Ambrohexal inhalations for children under 2 years of age

For babies, the drug can be prescribed exclusively by a doctor. Proportions for children of such an early age are selected by the doctor strictly on an individual basis.

The procedure is carried out exclusively with the help of a face mask, and it is allowed to apply the mask on the face of a sleeping child. This will facilitate the manipulation for both parents and crumbs.

2 to 6 years old

Otherwise, inhalation therapy sessions are carried out using a nozzle on the face.

Inhalations with Ambrohexal during pregnancy: how to do it?

For pregnant women, the drug is prescribed exclusively by a doctor if there are strong indications for its use, which may include not only a cough, but also a suspicion of the development of malnutrition in the fetus.

This is necessary because ambroxol promotes the early maturation of the lungs and prevents the onset of preterm labor.

The procedure is carried out according to the recommendations received from the doctor. Its course is similar to the above, but the dose is selected strictly individually.

Special instructions for use

The mucolytic effect, that is, the activation of sputum excretion, is enhanced by the use of large amounts of liquid. Therefore, while taking Ambrohexal, it is recommended to drink a lot, preferably water, but juices, tea, etc. are also suitable.

It is desirable that the last session of inhalation therapy be performed at least one hour before bedtime. Eating is possible 1.5 hours before the manipulation and after the same time after it.

Also, within an hour after it, you should not go out or smoke. If any violations or worsening of the condition occur, you should consult a doctor, but an increase in cough is not a reason to refuse treatment.

Analogues

Drops for inhalation are a fairly popular form of drug release, since the high efficiency of inhalation therapy has been proven by many studies and the practical experience of a huge number of doctors and patients.

Therefore, new drugs with a mucolytic effect are constantly entering the pharmaceutical market, including those based on ambroxol. It:

  1. Lazolvan;
  2. Bronchovern;
  3. Flavamed etc.

Also in the pharmacy you can buy these drugs in the form of tablets, capsules, syrup with different dosages.

You can often hear disputes: Lazolvan or Ambrohexal for inhalation, which is better? But they do not have a scientific background, since both medicines have the same active substance, so the effect of their use will be the same.

Interaction with other drugs

Medicines based on ambroxol are not recommended to be used simultaneously with antitussives, since they, acting on certain parts of the brain, provoke inhibition of the cough reflex.
Therefore, increased in volume, liquefied by ambroxol, sputum accumulates in the bronchi and lungs, making breathing difficult and leading to a deterioration in the patient's condition.

Thus, you should not combine, for example, Rengalin and Ambrohexal inhalation. The active ingredients of Rengalin are antibodies to various substances that provoke inhibition of the cough and pain centers of the brain.

It is advisable to use the drug for severe bacterial infections against the background of antibiotic therapy, as it helps to increase the concentration of erythromycin, amoxicillin and doxycillin in the bronchi.

This leads to an increase in the effectiveness of antibiotics and a speedy recovery.

But such a combination of drugs can only be prescribed by a qualified doctor who is able to correctly calculate the dosage of the antibiotic so as not to harm the patient.

Storage conditions and shelf life

The drug retains its properties for 4 years from the date of issue, after this period it is not recommended to use it. Store the solution in a dark place at a temperature not exceeding 25 °C.

Reviews that used the drug

When my child got sick with bronchitis, our pediatrician prescribed Ambrohexal. I have no complaints about the drug. All arranged. The daughter recovered quickly. Six months have passed and the disease has not returned. The solution for inhalation remained after that time. Therefore, I already managed to try a couple of times on myself when I had a cold.

I like it because the unpleasant symptoms are immediately relieved. Depending on the degree of health complications, additional drugs can be used. But inhalation therapy without aids could help me and my child. Evgenia, 32 years old

One Ambrohexal tablet contain ambroxol hydrochloride (active ingredient) - 0.03 g + excipients ( calcium hydrogen phosphate, corn starch, magnesium stearate, lactose monohydrate, sodium carboxymethyl starch, colloidal silicon dioxide).

Capsules(long-acting) contain the active substance - 0.075 g + excipients ( Eudragide RL30D, Triethyl Citrate, Titanium Dioxide, Eudragide RS30D, Red Iron Oxide, MCC, Magnesium Stearate ).

Syrup Ambrohexal. For 5 ml of active ingredient syrup - 0.015 mg + excipients ( , essence raspberry citric acid monohydrate, sorbitol solution, polyvidone, sodium metabesulfite, water, sodium hydroxide,).

Solution for inhalation and ingestion (one milliliter) contains the active substance - 7.5 mg + excipients ( citric acid, methyl parahydroxybenzoate, sodium disulfite, sodium hydroxide, purified water ).

Release form

  • Round and flat tablets(white, with rounded edges) with a risk on one side. Packs of 20, 30, 50 and 100 pieces.
  • White capsules from gelatin, inside - a white or pinkish powder. Packs of 10, 20, 50 or 100 pieces.
  • Transparent, slightly yellowish viscous syrup. In bottles of 100 or 250 ml, a measuring spoon is included.
  • Solution Ambrohexal for inhalation and oral administration - transparent, colorless. In vials with a dispenser and a measuring cup of 50 and 100 mg.

pharmachologic effect

Expectorant. Mucolytic.

Pharmacodynamics and pharmacokinetics

Active substance - ambroxol belongs to the group benzylamines . Restores the normal balance between serous and mucous component bronchial secretions , by increasing the secretion of the mucous membrane and directly affects the active cells in the glands of the bronchi. The substance stimulates the activity of special airway villi thereby facilitating its movement through the bronchi. Ambroxol hydrochloride also has the ability to reduce the viscosity of sputum by depolymerization of mucopolysaccharides . The amount of bronchial secretion does not increase, stimulation of the centers that cause increased coughing does not occur.

In a period of time from half an hour to three hours, when taken orally, the drug reaches its maximum concentration in the lungs. About 90% of the substance binds to blood proteins . Most of the drug is excreted by the kidneys after 6-11 hours, after taking in the form glucuronide (or unchanged), the rest is metabolized in the liver tissues.

Indications for use

What are the tablets prescribed for?

  • acute or chronic;
  • bronchiectasis ;
  • tracheitis ;
  • (deficiency of bronchial secretion);
  • for prevention before operations;
  • pregnant women when there is a threat of premature birth (28-34 weeks).

Contraindications

  • on the ambroxol and other components of the funds;
  • first trimester of pregnancy;
  • , diseases of the liver and kidneys;
  • children under 6 years old;
  • for children under 12 years of age, prolonged-release capsules are not recommended.

Side effects

  • nausea, pain in epigastric region , dry mouth , ;
  • dryness in the nasal cavity or, on the contrary, excessive secretion;
  • allergic reactions, incl. on the skin;
  • general weakness , dysuria .

When using syrup or drops, specific reactions to metabisulphite (, shock, loss of consciousness, nausea, asthma attacks ).

Application instruction of Ambrohexal (Way and dosage)

When you receive tablets the daily dose for an adult (over 12 years old) in the first three days is 90 mg per day, divided into 3 doses. Further, the dosage can be reduced to 60 mg. Children (from 6 years old) are prescribed 30-45 mg per day.

For capsules prolonged action, the main condition is to maintain the integrity of the shell when taken. Assign, as a rule, 75 mg of the drug (1 tab.) After meals, once a day. Not recommended for use by children under 12 years of age.

Syrup appoint adults (from 12 years old) 30 mg (2 scoops) 3 times a day, the first few days. Then - the same amount 2 times a day. The maximum daily dose is 60 mg.

Children from 5 years - 1 spoon 3 times a day, from 2 to 5 - half a spoon, up to 2 years - half a spoon 2 times a day.

According to the instructions for Ambrohexal for, adults are prescribed 80 drops 3 times a day, the first days, then 80 drops 2 times a day. Children under 12 years - 40 drops 3 times a day, up to 5 years - 20 drops 3 times a day, up to 2 years - 20 drops 2 times a day.

The solution for oral administration and inhalation can be diluted in tea, juice, milk or water.

How to dilute drops for inhalation?

The drug should be diluted 0.9% physical solution , in equal proportions of approximately 50% to 50%. The prepared solution should be heated to 40-50 degrees. Children should inhale vapors for 2-3 minutes, adults - up to five minutes.

For adults (over 5 years old), inhalations are performed twice a day, diluted with 50 drops.

For children under 5 years old, dilute 40 drops, inhalation - 2 times a day.

Do not use the drug in any of the types for more than five days, without supervision or consulting a doctor.

Overdose

Occurs extremely rarely.

The most frequently occurring symptoms: hypersalivation, vomiting, diarrhea, arterial hypotension . Treatment is according to the symptoms.

Interaction

Can be combined with drugs prescribed for bronchial asthma .